Two All-Star Games were played each season from 1959 through 1962. Players selected for
both games count a single All-Star season.
All-Star Game — Game 1 — July 7, 1959
AL Roster
25 players
| Pos | Player | Team | Played |
|---|---|---|---|
| P | Early Wynn HOF | Chicago White Sox | Yes |
| C | Gus Triandos | Baltimore Orioles | Yes |
| 1B | Bill Skowron | New York Yankees | Yes |
| 2B | Nellie Fox HOF | Chicago White Sox | Yes |
| 3B | Harmon Killebrew HOF | Washington Senators | Yes |
| SS | Luis Aparicio HOF | Chicago White Sox | Yes |
| LF | Minnie Miñoso HOF | Cleveland Indians | Yes |
| CF | Al Kaline HOF | Detroit Tigers | Yes |
| RF | Rocky Colavito | Cleveland Indians | Yes |
| — | Billy Pierce | Chicago White Sox | — |
| — | Bud Daley | Kansas City Athletics | Yes |
| — | Frank Malzone | Boston Red Sox | Yes |
| — | Gil McDougald | New York Yankees | Yes |
| — | Harvey Kuenn | Detroit Tigers | Yes |
| — | Hoyt Wilhelm HOF | Baltimore Orioles | — |
| — | Jim Bunning HOF | Detroit Tigers | Yes |
| — | Mickey Mantle HOF | New York Yankees | Yes |
| — | Pete Runnels | Boston Red Sox | Yes |
| — | Roy Sievers | Washington Senators | Yes |
| — | Ryne Duren | New York Yankees | Yes |
| — | Sherm Lollar | Chicago White Sox | Yes |
| — | Ted Williams HOF | Boston Red Sox | Yes |
| — | Vic Power | Cleveland Indians | Yes |
| — | Whitey Ford HOF | New York Yankees | Yes |
| — | Yogi Berra HOF | New York Yankees | — |
NL Roster
26 players
All-Star Game — Game 2 — August 3, 1959
AL Roster
33 players
NL Roster
30 players